Excerpts from papers published about Xylit•All chewing Gum

The intensified xylitol gum usage for 16 months was associated with a reduction of the mean DMFS score from 10.9 (at 40 months) to 9.3 (at 56 months, p = 0.0013) and a reduction in caries rate from 20.1 caries onsets per 1,000 surface-years (40-month period average rate) to 10.2 caries onsets per 1,000 surface-years. Mäkinen KK, Hujoel PP, Bennett CA, Isokangas P, Isotupa K, Pape HR Jr, Mäkinen PL.Caries Res. 1998;32(2):107-12

Xylitol chewing gum has been shown to reduce Streptococcus mutans levels and decay. Mäkinen KK, Hujoel PP, Bennett CA, Isokangas P, Isotupa K, Pape HR Jr, Mäkinen PL.Caries Res. 1998;32(2):107-12

Less caries was observed in children of mothers who chewed gums with xylitol as the single sweetener during the time of eruption of the first primary teeth compared with those who used gums containing fluoride, sorbitol and lower amounts of xylitol. Thorild I, Lindau B, Twetman S. Eur Arch Paediatr Dent. 2006 Dec;7(4):241-5

Xylitol inhibits transfer of cariogenic bacteria from person to person and reduces bacterial recolonization over time.. John DB Featherstone; BMC Oral Health 2006, 6(Suppl 1):S8doi:10.1186/1472-6831-6-S1-S8

Chewing gum with xylitol can reduce the amount of dental plaque and acid production in saliva in schoolchildren. Holgerson PL, Sjöström I, Stecksén-Blicks C, Twetman S.; Int J Paediatr Dent. 2007 Mar;17(2):79-85

Xylitol-sorbitol-containing gum increases plaque pH, Koparal E, Ertugrul F, Sabah E.; J Clin Pediatr Dent. 2000 Winter;24(2):129-32

A 14-day use of xylitol-containing chewing gums, corresponding to a daily amount of 5 grams of xylitol, could diminish glucose-initiated lactic acid formation in supragingival plaque in caries-active pre-school children. Twetman S, Stecksén-Blicks C. Oral Health Prev Dent. 2003;1(3):195-9

Chewing xylitol gum may reduce salivary S. mutans levels. Xylitol chewing gum may provide a feasible caries prevention method for preschool children. Autio JT; ASDC J Dent Child. 2002 Jan-Apr;69(1):81-6, 13

Habitual xylitol consumption by mothers was associated with a statistically significant reduction of the probability of mother-child transmission of MS assessed at two years of age. The effect was superior to that obtained with either chlorhexidine or fluoride varnish treatments performed as single applications at six-month intervals. Söderling E, Isokangas P, Pienihäkkinen K, Tenovuo J. Institut J Dent Res. 2001 Jul;80(7):1600-1.

There was a linear reduction in mutans streptococci levels in plaque and saliva with increasing frequency of xylitol gum use at a constant daily dose. Ly KA, Milgrom P, Roberts MC, Yamaguchi DK, Rothen M, Mueller G. ; BMC Oral Health. 2006 Mar 24;6:6

Chewing xylitol gum for 6 months continued to inhibit the growth of mutans streptococci in adults. Haresaku S, Hanioka T, Tsutsui A, Yamamoto M, Chou T, Gunjishima Y ; Caries Res. 2007;41(3):198-203.

Maintaining long-term caries-pathogen suppression is feasible with currently available commercial products and can be expected to result in significant caries inhibition . Hildebrandt GH, Sparks BS.; J Am Dent Assoc. 2000 Jul;131(7):909-16

Xylitol at 6.44 g/day and 10.32 g/day reduces mutans streptococci in plaque at 5 wks, and in plaque and unstimulated saliva at 6 mos. A plateau effect is suggested between 6.44 g and 10.32 g xylitol/day. Milgrom P, Ly KA, Roberts MC, Rothen M, Mueller G, Yamaguchi DK.; Dent Res. 2006 Feb;85(2):177-81.

The highest caries reductions were observed in subjects using xylitol.(in comparison with sorbitol) . Hayes C.; J Dent Educ. 2001 Oct;65(10):1106-9.

Xylitol chewing gum can reduce the levels of MS in plaque and saliva. Thaweboon S, Thaweboon B, Soo-Ampon S. ; Southeast Asian J Trop Med Public Health. 2004 Dec;35(4):1024-7

After using four tablets/day of xylitol gum for three weeks, the levels of S. mutans in the saliva of children in the high caries index subgroup decreased by 61.7 percent. Massoth D, Massoth G, Massoth IR, Laflamme L, Shi W, Hu C, Gu F. J Calif Dent Assoc. 2006 Mar;34(3):231-4

Habitual xylitol gum-chewing should be started at least one year before permanent teeth eruption. Hujoel PP, Mäkinen KK, Bennett CA, Isotupa KP, Isokangas PJ, Allen P, Mäkinen PL.; J Dent Res. 2001 Jul;80(7):1600-1.

The use of chewing gum containing xylitol, in caries-prevention programs can reduce the tooth decay epidemic. Ly KA, Milgrom P, Rothen M.; J Am Dent Assoc. 2008 May;139(5):553-63

The evidence is strong enough to support the regular use of xylitol-sweetened gum as a way to prevent caries, Burt BA;. J Am Dent Assoc. 2006 Feb;137(2):190-6

Long-term (39 months) use of xylitol-containing chewing-gum can reduce the growth of mutans streptococci in saliva and dental plaque, and lactobacilli-type bacteria in saliva, even if xylitol is used only on school days. Reduced bacterial growth was still observed 15 months following the termination of xylitol use. The results indicate a close biochemical relationship between xylitol and mutans streptococci, and suggest that a similar relationship may exist regarding aerobically cultured aciduric bacteria present in saliva. Mäkinen KK, Alanen P, Isokangas P, Isotupa K, Söderling E, Mäkinen PL, Wenhui W, Weijian W, Xiaochi C, Yi W, Boxue Z; Int Dent J. 2008 Feb;58(1):41-50

Xylitol's specific effects on oral flora add to its caries-preventive profile and give it a unique role in preventive strategies for dental health. A. Maguire1 and A. J. Rugg-Gunn2 British Dental.Journal 2003; Volume 194, No. 8, pages 429-436 doi: 10.1038/sj.bdj.4810022

The Michigan Xylitol Programme (1986-95) results suggest that the use of xylitol chewing gum can be considered a valuable additional tool in caries prevention and stabilization of caries in all age groups Albert E. Scott, Jr. U.S. Army Medical Department Journal, Jan-March, 2006 .